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KMID : 1007520080170010156
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Food Science and Biotechnology
2008 Volume.17 No. 1 p.156 ~ p.160
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Calcium Channel-blocking Activity of Chinese Balloon Flower (Platycodon grandiflorum) for Producing Blood Pressure-Lowering Functional Foods
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Kang Yoon-Seok
Hong Kwon-Pyo
Jung Dong-Chae
Hong Sung-Won
Lee Jun-Ho
Nah Seung-Yeal
Lim Yoong-Ho
Bae Dong-Ho
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Abstract
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This study was conducted to evaluate the hypotensive properties of the extract of Chinese balloon flower (Platycodon grandiflorum)`s root. In the studies for calcium channel-blocking using Xenopus oocytes, the ethanol-extract (26.2±5.2%) showed higher activity than water-extract. Twenty female rats were fed 25, 35, and 45 mg/kg BW/day of the ethanol-extract for 14 days to observe the changes in blood pressures and heart pulses. Ethanol-extract decreased the systolic, diastolic, and mean blood pressures of the rats. Especially, the rats fed with 45 mg/kg BW/day of the ethanol-extract showed significant decreases in the blood pressures. These results suggested that a decrease in blood pressures was due to the extension of a blood vessel with calcium channel-blocking by ethanol-extract of Chinese balloon flower. Forty %-ethanol showed the highest efficiency for ethanol-extraction of Chinese balloon flower.
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KEYWORD
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Chinese balloon flower, calcium channel-blocking, blood pressure, heart pulse, hypotensive property
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